DISITAMAB VEDOTIN COMBINED WITH PYROTINIB AS SALVAGE TREATMENT IN HER-2-AMPLIFIED TREATMENT REFRACTORY METASTATIC COLORECTAL CANCER: A CASE REPORT

Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal cancer (mCRC).Owing to the lack of established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments.Moreover, conventional chemotherapy regime

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Numerical Simulation and Experimental Study on Auxiliary Converter Cooling System of HXD1C Electric Locomotives

This paper determined the size of the heat sink of auxiliary converter of HXD1C locomotive.The required cooling air volume was new balance 990 v3 red calculated through experience formula.Three-dimensional calculation model for duct cooling systems numerical simulation had been set up by using CFD software FLUENT, which was used to solve the temper

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Differential Gene Expression in Red Imported Fire Ant (Solenopsis invicta) (Hymenoptera: Formicidae) Larval and Pupal Stages

Solenopsis invicta Buren is an invasive ant species that has been introduced to multiple continents.One such area, the southern United States, has a history of multiple control projects using chemical pesticides over varying ranges, often resulting in non-target effects across trophic levels.With the advent of next generation sequencing and RNAi te

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Localised estimates and spatial mapping of poverty incidence in the state of Bihar in India-An application of small area estimation techniques.

Poverty affects many people, but the ramifications and impacts affect all aspects of society.Information about the incidence of poverty is therefore an important parameter of the population for policy bee by bonnie and neil analysis and decision making.In order to provide specific, targeted solutions when addressing poverty disadvantage small area

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